Referred Journal Articles

  1. Gilkey, M. J.; Krishnan, V.; Scheetz L.; Jia, X.; Rajasekaran, A. K.; Dhurjati, P. S.* "Physiologically Based Pharmacokinetic Modeling of Fluorescently Labeled Block Copolymer Nanoparticles for Controlled Drug Delivery in Leukemia Therapy", CPT Pharmacometrics Syst Pharmacol, 2014, in press.
  2. Zerdoum, A. B.; Tong, Z.; Jia, X.* "Construction and Characterization of a Novel Vocal Fold Bioreactor", J. Vis. Exp., 2014, 90, e51594, doi:10.3791/51594. Link
  3. Xu, X.; Farach–Carson, M. C.; Jia, X.* "Three–Dimensional In Vitro Tumor Models for Cancer Research and Drug Evaluation", Biotechnol Adv, 2014, 32, 1256–1268. Link
  4. Zhang, H.; Dicker, K. T.; Xu, X.; Jia, X.*; Fox, J. M.* "Interfacial Bioorthogonal Crosslinking", ACS Macro Lett, 2014, 3, 727–731. Link
  5. Tong, Z.; Zerdoum, A. B.; Duncan, R. L.; Jia, X.* "Dynamic Vibration Cooperates with Connective Tissue Growth Factor to Modulate Stem Cell Behaviors", Tissue Eng Part A, 2014, 20, 1922–1934 Link
  6. Xu, X.; Sabanayagam, C. R.; Harrington, D. A.; Farach–Carson, M. C.; Jia, X.* "A Hydrogel–Based Tumor Model for the Evaluation of Nanoparticle–Based Cancer Therapeutics" Biomaterials, 2014, 35, 3319–3330. Link
  7. Dicker, K. T.; Gurski, L. A.; Pradhan–Bhatt, S.; Witt, R. L.; Farach–Carson, M. C.; and Jia, X.* "Hyaluronan: A Simple Polysaccharide with Diverse Biological Functions" Acta Biomaterialia, 2014, 10, 1558–1570. Link
  8. Pradhan–Bhatt, S.; Harrington, D. A.; Duncan, R. L.; Farach–Carson, M. C.; Jia, X.; Witt, R. L.* "A Novel In Vivo Model for Evaluating Functional Restoration of a Tissue Engineered Salivary Gland" The Laryngoscope, 2014, 124, 456–461. Link
  9. Xiao, L.; Tong, Z.; Chen, Y.; Pochan, D. J.; Sabanayagam, C. R.; Jia, X.* "Hyaluronic Acid–Based Hydrogels Containing Covalently Integrated Drug Depots: Implication for Controlling Inflammation in Mechanically Stressed Tissues" Biomacromolecules, 2013, 14, 3808–3819. Link
  10. Yang, X.; Xiao, L.; Jia, X.* "Designing Mechano–Responsive Materials with Elastomeric Properties for Biomedical Applications" SurFACTS in Biomaterials, 2013, 18, 7-8. Link
  11. Yang, X.; Cui, C.; Tong, Z.; Sabanayagam, C. R.; Jia, X.* "Poly(epsilon–Caprolactone)–Based Copolymers Bearing Pendant Cyclic Ketals and Reactive Acrylates for the Fabrication of Photocrosslinked Elastomers", Acta Biomaterialia, 2013, 9, 8232–8244. Link
  12. Tong, Z.; Duncan, R. L.; Jia, X.* "Modulating the Behaviors of Mesenchymal Stem Cells via the Combination of High Frequency Vibratory Stimulations and Fibrous Scaffolds", Tissue Eng Part A, 2013, 19, 1862–1878. Link
  13. Farran, A. J. E.; Teller, S. S.; Jia, F.; Clifton, R. J.; Duncan, R. L.; Jia, X.* "Design and Characterization of a Dynamic Vibrational Culture System", J. Tissue Eng Regen. M., 2013, 7, 213–225. Link
  14. Pradhan–Bhatt, S.; Harrington, D. A.; Duncan, R. L.; Jia, X.; Witt, R. L.; Farach–Carson, M. C*. "Implantable Three–Dimensional Salivary Spheroid Assemblies Demonstrate Fluid and Protein Secretory Responses to Neurotransmitters" Tissue Eng Part A, 2013, 19, 1610–1620. Link
  15. Krishnan, V.; Xu, X.; Barwe, S. P.; Yang, X.; Czymmek, K.; Waldman, S. A.; Mason, R. W.; Jia, X.; Rajasekaran, A. K.* "Dexamethasone–Loaded Block Copolymer Nanoparticles Induce Leukemia Cell Death and Enhances Therapeutic Efficacy: A Novel Application in Pediatric Nanomedicine", Mol. Pharm., 2013, 10, 2199–2210. Link
  16. Li, L.; Tong, Z.; Jia, X.; Kiick, K. L.* "Resilin–Like Polypeptide Hydrogels Engineered for Versatile Biological Functions", Soft Matter, 2013, 9, 665–673. Link
  17. Grieshaber, S. E.; Paik, B. A.; Bai, S.; Kiick, K. L.; Jia, X.* "Nanoparticle Formation from Hybrid, Multiblock Copolymers of Poly(acrylic acid) and a VPGVG Peptide" Soft Matter, 2012, 9, 1589–1599. Link
  18. Gurski, L. A.; Xu, X.; Labrada, L. N.; Nguyen, N. T.; Xiao, L.; van Golen, K. L.; Jia, X.; Farach–Carson, M. C.* "Hyaluronan (HA) Interacting Proteins RHAMM and Hyaluronidase Impact Prostate Cancer Cell Behavior and Invadopodia Formation in 3D HA–Based Hydrogels", PLoS One, 2012, 7, e50075. Link
  19. Xu, X.; Gurski, L. A.; Zhang, C.; Harrington, D. A.; Farach–Carson, M. C.; Jia, X.* "Recreating the Tumor Microenvironment in a Bilayer, Hyaluronic Acid Hydrogel Construct for the Growth of Prostate Cancer Spheroids", Biomaterials, 2012, 33, 9049–9060. Link
  20. Xiao, L.; Zhu, J.; Londono, D. J.; Pochan, D. J.; Jia, X.* "Mechano–Responsive Hydrogels Crosslinked by Self–Assembled Block Copolymer Micelles", Soft Matter, 2012, 8, 10233–10237. Link
  21. Teller, S. S.; Farran, A. J. E.; Xiao, L.; Jiao, T.; Duncan, R. L.; Clifton, R. J.; Jia, X.* "High Frequency Viscoelastic Shear Properties of Vocal Fold Tissues: Implications for Vocal Fold Tissue Engineering", Tissue Eng Part A, 2012, 18, 2008–2019. Link
  22. Tong, Z.; Jia, X.* "Biomaterials–Based Strategies for the Engineering of Mechanically Active Soft Tissues", MRS Commun, 2012, 2, 31–39. Link
  23. Grieshaber, S. E.; Farran, A. J. E.; Bai, S.; Kiick, K. L.*; Jia, X.* "Tuning the Properties of Elastin Mimetic Hybrid Copolymers via a Modular Polymerization Method", Biomacromolecules, 2012, 13, 1774–1786. Link
  24. Xu, X.; Jha, A. K.; Harrington, D. A.; Farach–Carson, M. C.; Jia, X.* "Hyaluronic Acid–Based Hydrogels: from a Natural Polysaccharide to Complex Networks", Soft Matter, 2012, 8, 3280–3294. Link
  25. Srinivasan, P. P.; McCoy, S. Y.; Jha, A. K.; Yang, W.; Jia, X.*; Farach–Carson, M. C.; Kirn–Safran, C. B.* "Injectable Perlecan Domain 1–Hyaluronan Microgels Potentiate the Cartilage Repair Effect of BMP2 in a Murine Model of Early Osteoarthritis", Biomed. Mater. 2012, 7, 024109 (11pp). Link
  26. Tong, Z.; Sant, S.; Khademhosseini, A.*; Jia, X.* "Controlling the Fibroblastic Differentiation of Mesenchymal Stem Cell via the Combination of Fibrous Scaffolds and Connective Tissue Growth Factor", Tissue Eng Part A, 2011, 17, 2773–2785. Link
  27. Krishna, O. D.; Jha, A. K.; Jia, X.*; Kiick, K. L.* "Integrin–Mediated Adhesion and Proliferation of Human MSC Elicited by a Hydroxyproline–Lacking, Collagen–like Peptide", Biomaterials, 2011, 32, 6412–6424. Link
  28. Xu, X.; Jha, A. K.; Duncan, R. L.; Jia. X.* "Heparin–Decorated, Hyaluronic Acid–Based Hydrogel Particles for the Controlled Release of Bone Morphogenetic Protein 2", Acta Biomater, 2011, 7, 3050–3059. Link
  29. Li, L.; Teller, S.; Clifton, R. J.; Jia, X.; Kiick, K. L.* "Tunable Mechanical Stability and Deformation Response of a Resilin–based Elastomer", Biomacromolecules, 2011, 12, 2302–2310. Link
  30. Greene, A. C.; Zhu, J.; Pochan, D. J.; Jia, X.*; Kiick, K. L.* "Poly(Acrylic Acid–b–Styrene) Amphiphilic Multiblock Copolymers as Building Blocks for the Assembly of Discrete Nanoparticles", Macromolecules, 2011, 44, 1942–1951. Link
  31. Wang, X.; Gurski, L. A.; Zhong, S.; Xu, X.; Pochan, D. J; Farach–Carson, M. C.; Jia, X.* "Amphiphilic Block Co–polyesters Bearing Pendant Cyclic Ketal Groups as Nanocarriers for Controlled Release of Camptothecin", J. Biomat. Sci.–Polym. E, 2011, 22, 1275–1298. Link
  32. Jha, A. K.; Xu, X.; Duncan, R. L.; Jia, X.* "Controlling the Adhesion and Differentiation of Mesenchymal Stem Cells Using Hyaluronic Acid–based, Doubly Crosslinked Networks", Biomaterials, 2011, 32, 2466–2478. Link
  33. Grieshaber, S. E.; Nie, T.; Yan, C.; Zhong, S.; Teller, S. S.; Clifton, R. J.; Pochan, D. J.; Kiick, K. L.; Jia, X.* "Assembly Properties of Alanine–Rich, Lysine–Containing Peptide and the Formation of Peptide/Polymer Hybrid Hydrogels", Macromol. Chem. Phys., 2011, 212, 229–239. Link
  34. Xiao, L.; Liu, C.; Zhu, J.; Pochan, D. J.; Jia X.* "Hybrid, Elastomeric Hydrogels Crosslinked by Multifunctional Block Copolymer Micelles", Soft Matter, 2010, 6, 5293–5297. Link
  35. Jha, A. K.; Malik, M. S.; Farach–Carson, M. C.; Duncan, R. L.; Jia, X.* "Hierarchically Structured, Hyaluronic Acid–Based Hydrogel Matrices via the Covalent Integration of Microgels into Macroscopic Networks", Soft Matter, 2010, 6, 5045–5055. Link
  36. Luo, Y.*; Kobler, J. B.; Heaton, J. T.; Jia, X.; Zeitels, S. M.; Langer, R. "Injectable Hyaluronic Acid–Dextran Hydrogels and Effects of Implantation in Ferret Vocal Fold" J. Biomed. Mater. Res. B 2010, 93B, 386–393. Link
  37. Pradhan, S.; Liu, C.; Zhang, C.; Jia, X.; Farach–Carson, M. C.; Witt, R. L.* "Lumen Formation in Three–Dimensional Cultures of Salivary Acinar Cells", Otolaryngol. Head Neck Surg. 2010, 142, 191–195. Link
  38. Gurski, L. A.; Petrelli, N. J.; Jia, X.; Farach–Carson, M. C.* "3D Matrices for Anti–Cancer Drug Testing and Development" Oncology Issues, 2010, 25, 20–25. Link
  39. Farran, A. J. E.; Teller, S. S.; Jha, A. K.; Jiao, T.; Hule, R. A.; Clifton, R. J.; Pochan, D. J.; Duncan, R. L.; Jia, X.* "Effects of Matrix Composition, Microstructure and Viscoelasticity on the Behaviors of Vocal Fold Fibroblasts Cultured in Three–Dimensional Hydrogel Networks", Tissue Eng Part A, 2010, 16, 1247–1261. Link
  40. Jha, A. K.; Yang, W.; Kirn–Safarn, C. B.; Farach–Carson, M. C.; Jia, X.* "Perlecan Domain I–Conjugated, Hyaluronic Acid–Based Hydrogel Particles for Enhanced Chondrogenic Differentiation via BMP–2 Release" Biomaterials, 2009, 30, 6964–6974. Link
  41. Pradhan, S.; Zhang, C.; Jia, X.; Carson, D. D.; Witt, R.; Farach–Carson, M. C.* "Perlecan Domain IV Peptide Stimulates Salivary Gland Cell Assembly in vitro" Tissue Eng Part A. 2009, 15, 3309–3320. Link
  42. Gurski, L. A.; Jha, A. K.; Zhang, C.; Jia, X.; Farach–Carson, M. C.* "Hyaluronic Acid Hydrogel as 3D Matrices for in vitro Evaluation of Chemotherapeutic Drugs Using Poorly Adherent Cells" Biomaterials, 2009, 30, 6076–6085. Link
  43. Grieshaber, S. E.; Farran, A. J. E.; Lin–Gibson, S.; Kiick, K. L.*; Jia, X.* "Synthesis and Characterization of Elastin–Mimetic Hybrid Polymers with Multiblock, Alternating Molecular Architecture and Elastomeric Properties" Macromolecules, 2009, 42, 2532–2541. Link
  44. Jia, X.*; Kiick, K. L.*; "Hybrid Multicomponent Hydrogels for Tissue Engineering", Macromol. Biosci., 2009, 9, 140–156. Link
  45. Jiao, T.*; Farran, A.; Jia, X.; Clifton, R. J. "High Frequency Measurements of Viscoelastic Properties of Hydrogels for Vocal Fold Regeneration" Exp. Mech. 2009, 49, 235–246.
  46. Jha, A. K.; Hule, R. A; Jiao, T.; Teller, S. S.; Clifton, R. J.; Duncan, R. L.; Pochan, D. J.; Jia, X.* "Structural Analysis and Mechanical Characterization of Hyaluronic Acid–Based Doubly Cross–Linked Networks", Macromolecules, 2009, 42, 537–546.
  47. Sahiner, N.; Jha, A. K.; Nguyen, D.; Jia, X.* "Fabrication and Characterization of Cross–Linkable Hydrogel Particles Based on Hyaluronic Acid: Potential Application in Vocal Fold Regeneration" J. Biomat. Sci.– Polym. E. 2008, 19, 223–243.
  48. Ni, C.*; Li, X.; Chen, Z.; Li, H.–Y. H.; Jia, X.; Shah, I.; Xiao, J. Q. "Oriented Polycrystalline Mesoporous CeO2 with Enhanced Pore Integrity" Micropor. Mesopor. Mat. 2008, 115, 247–252.
  49. Goldberg, M.; Langer, R.; Jia, X.* "Nanostructured Materials for Applications in Drug Delivery and Tissue Engineering", J. Biomat. Sci.–Polym. E. 2007, 18, 241–268.
  50. Jia, X.*; Yeo, Y.; Clifton, R. J.; Jiao, T.; Kohane, D. S.; Kobler, J. B.; Zeitels, S. M.; Langer, R. "Hyaluronic Acid–Based Microgels and Microgel Networks for Vocal Fold Regeneration", Biomacromolecules, 2006, 7, 3336–3344.
  51. Jia, X.*; Herrera–Alonso, M.; McCarthy T. J. "Nylon Surface Modification, Part 1: Targeting the Amide Groups for Selective Introduction of Reactive Functionalities", Polymer, 2006, 47, 4916–4924.
  52. Herrera–Alonso, M.; McCarthy T. J.; Jia, X.*; "Nylon Surface Modification: 2, Nylon–Supported Composite Films", Langmuir, 2006, 22, 1646–1651.
  53. Clifton, R. J.*, Jiao T., Bull, C., Jia, X., "Vocal Fold Bioengineering", Science & Medicine, 2005, 10, 149–152.
  54. Burdick, J. A.; Chung, C.; Jia, X.; Randolph, M. A.; Langer, R.* "Controlled Degradation and Mechanical Behavior of Photopolymerized Hyaluronic Acid Networks" Biomacromolecules, 2005, 6, 386–391.
  55. Jia, X.; Burdick, J. A.; Kobler, J.; Clifton, R. J.; Rosowski, J. J.; Zeitels, S. M.; Langer, R.* "Synthesis and Characterization of in Situ Cross–Linkable Hyaluronic Acid–Based Hydrogels with Potential Application for Vocal Fold Regeneration" Macromolecules, 2004, 37, 3239–3248.
  56. Jia, X.; Colombo, G.; Padera, R.; Langer, R.; Kohane, D. S.* "Prolongation of Sciatic Nerve Blockade by in Situ Cross–Linked Hyaluronic Acid" Biomaterials, 2004, 25, 4797–4804.
  57. Kim, D. H.; Jia, X.; Lin, Z.; Guarini, K.W.; Russell, T. P.* "Growth of Silicon Oxide in Thin Film Block Copolymer Scaffolds" Adv. Mater. 2004, 16, 702–706.
  58. Jia, X.; McCarthy, T. J.* "Controlled Growth of Silicon Dioxide from "Nanoholes" in Silicon–Supported Tris(trimethylsiloxy)silyl Monolayers: Rational Control of Surface Roughness at the Nanometer Length Scale" Langmuir, 2003, 19, 2449–2457.
  59. Ming, W.*; Tian, M.; van de Grampel, R. D.; Melis, F.; Jia, X.; Loos, J.; van der Linde, R. "Low Surface Energy Polymeric Films from Solventless Liquid Oligoesters and Partially Fluorinated Isocyanates" Macromolecules, 2002, 35, 6920–6929.
  60. Jia, X; McCarthy, T. J.* "Buried Interface Modification Using Supercritical Carbon Dioxide" Langmuir, 2002, 18, 683–687.
  61. Kim, H. C.; Jia, X.; Stafford C. M.; Kim, D. H.; McCarthy, T. J.; Tuominen, M.; Hawker, C. J.; Russell, T. P.* "A Route to Nanoscopic SiO2 Posts via Block Copolymer Templates" Adv. Mater., 2001, 13, 795–797.
  62. Jia, X.; Pang, Y.; Huang, J.* "Copolymerization of Ethyl α–(Hydroxymethyl)acrylate with Maleimide and Characterization of the Resulting Copolymer" J. Polym. Sci. A1, 1998, 36, 1291–1299.
  63. Jiang, J.; Jia, X.; Pang, Y.; Huang, J.* "Alternating Copolymerization of Maleimide and Ethyl Atropate without Initiator" J. Macromol. Sci. Pure, 1998, A35, 781–792.

Books and Book Chapters

  1. Grieshaber, S. E.; Jha, A. K.; Farran, A. J. E.; Jia, X. "Hydrogels in Tissue Engineering" in "Biomaterials for Tissue Engineering: A review of the past and future trends" Burdick, J. A.; Mauck, R. L. Eds. Springer, 2011, 9–46 (ISBN: 978–3–7091–0384–5).
  2. Farran, A. J. E.; Tong, Z.; Witt, R. L.; Jia, X. "Tissue Engineering Strategies for Vocal Fold Repair and Regeneration" in "Engineering Biomaterials for Regenerative Medicine: Novel Technologies for Clinical Applicaations" Bhatia, S. K. Ed., Springer, 2012, 253–284 (ISBN: 978–1–4614–1080–5).


  1. Kirn–Safran, C. B.; Farach–Carson, M. C.; Jia, X.; Srinivasan, P. P.; Jha, A. J. "Injectable Delivery System for Heparin–Binding Growth Factors", Provisional Patent Application, US 61/453,340, April 14, 2011.
  2. Jia, X.; Jia, M.; Jha, A. K.; Farran, A. J. E.; Tong, Z. "Dynamic Vibrational Method and Device for Vocal Fold Tissue Growth" Nonprovisional Patent Application, US 12/781,305, May 15, 2010.