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Professor Catherine Grimes (right), director of UD’s Chemistry-Biology Interface (CBI) Program, works with doctoral student Marina Vasconcelos on research to repurpose an Alzheimer’s drug for potential use in treating patients with Crohn’s disease.
Professor Catherine Grimes (right), director of UD’s Chemistry-Biology Interface (CBI) Program, works with doctoral student Marina Vasconcelos on research to repurpose an Alzheimer’s drug for potential use in treating patients with Crohn’s disease.

Training innovators in science and medicine

Photos by Kathy F. Atkinson and courtesy of Ann O’Brien and Phillip Taylor

UD program marks 30 years of excellence

Some fascinating events marked the year 1995: The comet Hale-Bopp was discovered, the first full-length movie created entirely using computer animation, Toy Story, premiered, and the global pop star Dua Lipa was born. 

At the University of Delaware, a program to develop a new kind of researcher for the scientific workforce also began ramping up then, with support from UD and America’s largest medical research agency, the National Institutes of Health (NIH). 

The late research pioneer Roberta (“Bobbie”) Colman, Willis F. Harrington Professor of Chemistry and Biochemistry at UD, had written a successful proposal to NIH, securing one of the first Chemistry-Biology Interface programs in the nation. 

Today, UD’s CBI Program is part of a network of 35 programs located at universities across the United States. The goal of this training program for doctoral students is to produce chemists, engineers and biologists who can lead the charge in applying fundamental science to cutting-edge technology and therapeutic development — from growing artificial organs to curing chronic diseases.

As just one example, researchers with expertise in both chemistry and biology are driving advancements in precision medicine, which matches medical treatment to a person’s unique genetic profile. Having a biology background is important for diagnosing disease, while a chemistry background is important for designing the molecules that act as chemical probes for studying how disease cells and potential drug therapies interact. The precision diagnostics and medicine market is projected to reach nearly $250 billion in 2029.

“The University of Delaware wants its students to become leaders impacting society, and our students are great exemplars,” said CBI Program Director Catherine Leimkuhler Grimes, professor in the Department of Chemistry and Biochemistry. “Some have gone into the biotechnology and pharmaceutical industries, others have stayed in academia to train the next wave of students, and still others have gone into policy-making and patent law.”

A focus on student success

The “CBI experience” at UD immediately connects doctoral students into a community of collaboration and support. They participate in lab rotations that expose them to different disciplines, attend seminars on topics ranging from research rigor and reproducibility to science communication, take part in career development workshops and retreats, and pursue a multi-week sabbatical to learn a new technique on an academic campus or in an industrial setting. 

During its 30-year history, the program, started by Colman, subsequently has been led by professors John Koh and Brian Bahnson, and then co-led by Bahnson and Grimes. Along the way, it has trained more than 180 scientists.

The “CBI experience” at UD connects students to a community of scholars through lab rotations, seminars on research ethics to communications, career development workshops, retreats and social events such as holiday gatherings.
The “CBI experience” at UD connects students to a community of scholars through lab rotations, seminars on research ethics to communications, career development workshops, retreats and social events such as holiday gatherings.

Now, Grimes directs the program with mentorship from the former directors. She fondly recalls when Colman took her to dinner in 2012, advising her to work hard to recruit the best faculty talent to engage with the program. Heeding that advice, Grimes recruited four professors as co-directors — April Kloxin from the Department of Chemical and Biomolecular Engineering, Jessica Tanis from the Department of Biological Sciences, and Don Watson and Lauren Genova from the Department of Chemistry and Biochemistry.

This team, along with program coordinator Jessica Pappas, keeps the curriculum fresh and relevant, with input from 50 affiliated faculty and an external advisory board from industry and other academic institutions. 

Also unique to UD’s program are mentoring “grand rounds,” which bring together program leaders and faculty to discuss the best ways to support student success in an anonymized way. 

“People here take mentoring very seriously, and we think about doing things in new ways,” Grimes said.

UD’s program was the first in the national CBI network to admit engineering students, as well as to admit students in a two-track system, where they can choose between distinct career pathways. 

All of this, Grimes said, has allowed the program “to be inclusive for every student and to grow different types of scientists.”

The ability to see and experience different labs was the primary attraction for Marina Vasconcelos when she was applying to graduate school.

Now in the third year of her doctoral program in chemistry and biochemistry at UD, Vasconcelos is doing research on Crohn’s disease, a chronic inflammatory bowel disease. She has already helped to secure research funding for the Grimes lab from the Crohn’s and Colitis Foundation. 

She wants to become a medical science liaison, a kind of unbiased scientific adviser who serves as a bridge between pharmaceutical companies and physicians. 

“It’s a role where you need to know the science behind a disease, with the ability to communicate to the companies what physicians are seeing in the clinic and want to see researched, and to share back with the physicians what the companies want to know,” she said.

Vasconcelos has already gone on a CBI “sabbatical” at Johns Hopkins University to work with a physician-scientist who approaches her science in a very clinical way. 

The program has made other important impacts. She got her beloved dog, Princess, thanks to a fellow CBI student whose aunt operates a Corgi rescue.

The foundation for an industry career

For Ann O’Brien, senior director of analytical development at Incyte, the CBI program helped her find her niche. She was a student in the program from 2002–2007.

When she started grad school at UD, O’Brien had already worked in industry as an analytical chemist for a few years and wanted to prepare herself for the next level.

UD alumna Ann O’Brien, senior director of analytical development at Incyte, credits the Chemistry-Biology Interface Program for providing the foundation for “where my career took off.”
UD alumna Ann O’Brien, senior director of analytical development at Incyte, credits the Chemistry-Biology Interface Program for providing the foundation for “where my career took off.”

“I wasn’t sure what I wanted to pursue. I just wanted to learn more,” she said. “The opportunities to do rotations and be exposed to different research in how to solve complex problems in biological systems provided the foundation for where my career took off.” 

Getting the perspectives of world-class investigators, including chemical engineer Bramie Lenhoff and chemists Mary Wirth and Murray Johnston, was “really, really important” and so was the requirement for students to present their projects.

“It helped me to tell a story about my research, so an audience could become interested very quickly,” O’Brien said. “It was so beneficial. In industry, you do that on a regular basis.” 

After graduating, she went to Merck to work on a new type of chemistry for the application of novel therapeutic agents, then to DuPont to do basic research in biological engineering and sustainable materials, and then to Incyte to bring medicines to patients with unmet medical needs.  

“It’s a special thing to think back about how this program provided the foundation for the next step, and the next step, and the next step,” O’Brien said. “If you think about the world today, most of the phenomenal changes are coming from cross-functional areas — like electric cars. If everybody just stays in their lane all the time, you will not have all these life-changing, world-changing innovations. The CBI program really helped me connect the dots.”

The career he always wanted

The CBI program helped Phillip Taylor prepare for the academic career he’s always wanted. 

Taylor received his Ph.D. in chemical and biomolecular engineering at UD in 2022 and now is an assistant professor in the University of Virginia’s Department of Chemical Engineering.

UD’s Chemistry-Biology Interface Program was instrumental in helping Phillip Taylor achieve his dream to become a professor. The UD alum is now on the chemical engineering faculty at the University of Virginia.
UD’s Chemistry-Biology Interface Program was instrumental in helping Phillip Taylor achieve his dream to become a professor. The UD alum is now on the chemical engineering faculty at the University of Virginia.

When he started his doctoral program at UD, Taylor knew he wanted to work on medical applications, but he didn’t know what lab to join. The CBI program helped him make connections.

His doctoral research focused on biomaterials for drug delivery and tissue engineering applications. He used computational tools to design materials similar to collagen and tissue-like proteins, then the scaffolds for them to grow on, and the particles for delivering drugs in the body.

In the process, he went from a bio-heavy background to a materials science one, thanks to his faculty advisers, Arthi Jayaraman and April Kloxin, as well as lab rotations with Kristi Kiick and Millie Sullivan — all in the College of Engineering. 

“Getting direct feedback for this work was a huge selling point for the program,” he said. 

The sense of community and the opportunity to mentor younger CBI students were additional pluses. 

“I really love mentorship and teaching,” said Taylor, who gave a seminar at UD recently. “I’m thankful for my time at CBI, and I still see the faculty there as my mentors.”

Program graduates also have become research professors at the University of Arizona, Villanova, Layfette and the College of Wooster, Grimes said.

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