Aditya Dutta
Aditya Dutta
Office location:
531 S. College Avenue
050 Townsend Hall
Newark, DE 19716
Resources and links
Education
- Postdoctoral training - Reproductive Cancer Biology - Columbia University
- Ph.D - Biochemistry, Cellular & Molecular Biology - Syracuse University
- M.Sc - Biotechnology - Indian Institute of Technology Bombay
- B.Sc - Biochemistry (honors) - University of Delhi
Current courses
- ANFS 345 - Animal Physiology
- ANFS 441 - Reproductive Physiology
- ANFS 475/675 - Veterinary Biochemistry
- ANFS 865 - Graduate Seminar
Research
Research in the Dutta laboratory is focused on understanding the mechanistic basis of cellular response to oxidative stress in both normal and diseased states, and the role of the microbiome in this process. In particular, the laboratory studies mitochondria-mediated mechanisms involved in the development and maintenance of reproductive organ systems. The laboratory utilizes state-of-the-art transcriptomic, proteomic, and metabolomic approaches to interrogate chicken models, mouse models, and human samples. The work aims to improve reproductive efficiency in chickens to enhance farm productivity; and identify and define drivers of prostate and ovarian cancer in the human context.
Dutta A, Choudhary P, Gupta-Bouder P, Chatterjee S, Liu PP, Klessig DF, Raina R. Arabidopsis SMALL DEFENSE-ASSOCIATED PROTEIN 1 Modulates Pathogen Defense and Tolerance to Oxidative Stress. Front Plant Sci. 2020 Jun 3;11:703. doi: 10.3389/fpls.2020.00703. PMID: 32582244; PMCID: PMC7283558.
Le Magnen C, Virk RK, Dutta A, Kim JY, Panja S, Lopez-Bujanda ZA, Califano A, Drake CG, Mitrofanova A, Abate-Shen C. Cooperation of loss of NKX3.1 and inflammation in prostate cancer initiation. Dis Model Mech. 2018 Nov 16;11(11):dmm035139. doi: 10.1242/dmm.035139. PMID: 30266798; PMCID: PMC6262819.
Dutta A, Choudhary P, Caruana J, Raina R. JMJ27, an Arabidopsis H3K9 histone demethylase, modulates defense against Pseudomonas syringae and flowering time. Plant J. 2017 Sep;91(6):1015-1028. doi: 10.1111/tpj.13623. Epub 2017 Aug 7. PMID: 28650521.
Dutta A, Panja S, Virk RK, Kim JY, Zott R, Cremers S, Golombos DM, Liu D, Mosquera JM, Mostaghel EA, Barbieri CE, Mitrofanova A, Abate-Shen C. Co-clinical Analysis of a Genetically Engineered Mouse Model and Human Prostate Cancer Reveals Significance of NKX3.1 Expression for Response to 5α-reductase Inhibition. Eur Urol. 2017 Oct;72(4):499-506. doi: 10.1016/j.eururo.2017.03.031. Epub 2017 Apr 4. PMID: 28385453; PMCID: PMC5600823.
Dutta A, Le Magnen C, Mitrofanova A, Ouyang X, Califano A, Abate-Shen C. Identification of an NKX3.1-G9a-UTY transcriptional regulatory network that controls prostate differentiation. Science. 2016 Jun 24;352(6293):1576-80. doi: 10.1126/science.aad9512. PMID: 27339988; PMCID: PMC5507586.
Le Magnen C, Dutta A, Abate-Shen C. Optimizing mouse models for precision cancer prevention. Nat Rev Cancer. 2016 Mar;16(3):187-96. doi: 10.1038/nrc.2016.1. Epub 2016 Feb 19. PMID: 26893066; PMCID: PMC5517771.
Dutta A, Chan SH, Pauli NT, Raina R. Hypersensitive response-like lesions 1 codes for AtPPT1 and regulates accumulation of ROS and defense against bacterial pathogen Pseudomonas syringae in Arabidopsis thaliana. Antioxid Redox Signal. 2015 Mar 20;22(9):785-96. doi: 10.1089/ars.2014.5963. Epub 2015 Feb 11. PMID: 25557512; PMCID: PMC4361009.