Jeffrey Mugridge
Biography
B.S. - University of Chicago (2006, Chemistry); Ph.D. - University of California Berkeley (2010, Chemistry); NIH Postdoctoral Fellow - University of California, San Francisco (2011 - 2019, Biochemistry & Structural Biology)
Current Research
Research in the Mugridge lab takes an interdisciplinary approach to understand how the cell controls RNA function to regulate gene expression. We combine techniques from biochemistry, structural biology, biophysics, and chemistry to answer challenging mechanistic questions about macromolecular RNA-protein complexes and their links to human disease. In particular, we are working to answer questions that include:
(1) How does the cell read, write, and erase diverse chemical modifications on mRNA and tRNA to impact RNA structure, translation, and stability?
(2) How are defects in RNA modification pathways and RNA-modifying enzymes linked to human diseases and how can we use mechanistic, atomic-level insights to help treat those diseases?
And (3) how can we develop new chemical and biochemical tools to selectively and quantitatively monitor dynamic changes to RNA in the cell?
Representative Publications
Mugridge JS, Coller J, Gross JD. Structural and molecular mechanisms for the control of eukaryotic 5'-3' mRNA decay. Nature Structural & Molecular Biology (2018), 25(12), 1077-1085.
Mugridge JS, Tibble RW, Ziemniak M, Jemielity J, Gross JD. Structure of the activated Edc1-Dcp1-Dcp2-Edc3 mRNA decapping complex with substrate analog poised for catalysis. Nature Communications (2018), 9(1), 1152.
Mugridge JS, Ziemniak M, Jemielity J, Gross JD. Structural basis of mRNA-cap recognition by Dcp1-Dcp2. Nature Structural & Molecular Biology (2016), 23(11), 987-994.
