Tuesdays and Thursdays, 2-3:15 p.m.
074 Drake Hall
Instructor: John McDonald
322 Wolf Hall (office)
Phone: 831-2007 (I rarely check messages, so e-mail is better)
Class web page: http://udel.edu/~mcdonald/evolsyllabus.html
General format: For the first half of the semester, I'll be giving lectures on some of the basic concepts of evolutionary genetics: methods of detecting genetic variation, natural selection, random drift and the neutral model, and estimation of phylogenies.
For the second half of the semester, we will discuss two articles from the original scientific literature at each class. Each of you will pick three articles from the evolutionary genetics literature by Tuesday, Feb. 24; I'll then assign you one of the articles you've chosen, group the articles by topic and assign you dates for your presentations. You will research the literature on the topic of your article and write a paper about it. You'll turn in the paper one week before your presentation. Every other student will read the articles and participate in the discussions. Half of the students who aren't presenting on a particular day will write a short (two pages) critique of the two articles.
Exam: There will be an exam on the lecture material on Thursday, March 26. I will post a study guide, with sample questions, in a week or two.
Paper: You must choose three possible articles on three different topics in evolutionary genetics, and rank them from your first to last choice. You must print out the citation information (authors, year, article title, journal name, volume and page numbers) and the abstracts and turn it in on Tuesday, Feb. 24.
I will try to give everyone their first choice of paper, but to ensure that we don't have too many papers on similar topics, some people will have to do their second or third choice paper. I will let you know which paper you are doing.
You will then research the literature on the topic of that article, and write a paper about it, summarizing the relevant literature. This paper will be due one week before your presentation, so I have time to grade it and return it to you with suggestions for improving your presentation. See the instructions for the papers for more details.
I strongly urge you to schedule a meeting with me before you begin the literature research for your paper and class presentation. I can suggest some background reading and help you see what the main focus of your paper and presentation should be.
Presentations: When it is your turn to lead the discussion, you should present background information about the topic of your paper for about 10 to 15 minutes, then open the floor for discussion. If you and your partner for the day have papers on similar topics, you should discuss your presentations ahead of time so that you don't both present the same information. Since everyone will have read the paper in depth beforehand, you should NOT describe what the assigned paper says. Instead, you should present background information from earlier papers that is important for understanding your paper, and you should summarize more recent work on the topic of your paper (if there is some). During the discussion, you should make sure that everyone gets a chance to participate, and should also recognize when the discussion is dwelling on minor points or bogging down and pose questions that will get things back on track.
To present visual information as part of your presentation, you may use the chalkboard, overheads, PowerPoint (for Windows or Macintosh), Keynote (for Macintosh), or OpenOffice.org Impress (for Windows or Macintosh). If you are going to use PowerPoint, Keynote or Impress, e-mail the file to me by 9 a.m. on the day of your presentation, and if possible, bring the file to class on a flash drive or CD as a backup in case the e-mail doesn't work.
The presentation will be worth 15 percent of your grade, based on the thoroughness of your preparation, your effective use of visual aids (note that "effective" does not mean "flashy"; sometimes a simple chalkboard drawing is all you need), and your ability at leading a discussion.
Critiques: To sharpen your critical and writing skills, you will be required to turn in a critique of four of the pairs of papers, at the end of class on the day of the discussion. If your presentation is on a Tuesday, you will write critiques for every Tuesday's papers (except not your own Tuesday); if your presentation is on a Thursday, you'll critique every Thursday's papers (except not your own Thursday). Each critique must be typed and at least two single-spaced pages long (total for the two papers, not two pages per paper) and must do all of the following:
The critiques should not spend more than a couple of sentences summarizing the content of each paper; the goal is to critique the paper, not explain it to me.
Participation: Your participation in the class discussions after spring break will count for 10 percent of your grade. If you say something in every discussion class, you'll get the full 10 percent; to encourage uninhibited discussion, I'm not going to grade the content of your comments.
Integrity: If you copy another student's work or cheat in some other way on the exam, you will receive an F for the course. See the term paper instructions for the policy on plagiarism.
Grading philosophy: I view grades as a form of communication, a way for me to tell others (your future employers or schools you apply to) how well you have learned the skills and concepts this class is teaching you. An "A" is my way of saying, "Dear person of the future: this person took my Evolutionary Genetics class and learned everything I wanted them to learn." If I were the world's best teacher, every student would learn everything, and the grade roster for this class would have 19 A's on it. That is my goal. I will not grade on a curve; I see no reason that there should be mostly C's and B's, with a few A's and D's for symmetry, and just enough F's to prove that I'm tough. If everyone does well on the exam, presentation, and writing assignments, everyone will get an A; if everyone does poorly, everyone will get an F. So far, I have not been the world's best teacher; I'll try to make this year different. Please help me by asking for my assistance if you have trouble understanding the material or doing the assignments.
Grades: Your grade will be based on the following:
Paper topic choice: 3 points
Exam: 30 points
Paper: 32 points
Presentation: 15 points
Critiques: 10 points
Participation: 10 points
Grade scale: A 93-100; A- 90-92.9; B+ 87-89.9; B 83-86.9; B- 80-82.9; C+ 77-79.9; C 73-76.9; C- 70-72.9; D+ 67-69.9; D 63-66.9; D- 60-62.9; F 0-59.9.
Students who are less than 3 points below the minimum grade needed for their program (such as an undergraduate biology major with 67 to 69.9 points) will be given the opportunity to take an incomplete grade and complete an extra credit project. This project will be a lot of work, such as writing a 15-page term paper on a topic of my choice. Upon satisfactory completion of the project, you'll get the minimum grade needed for your program (such as C- for undergraduate biology majors). There will be no other extra credit.
Attendance: You are not required to attend the lectures, but I don't think you'll be able to do very well on the exam if you skip them. Because all the material on the exams will come from the lectures (there is no textbook), I recommend getting the lecture notes from someone else if you have to miss a class. In the second half of the semester, you will lose participation points for unexcused absences. If you miss a class during the second half of the semester, write a note on the next critique you turn in, explaining the reason for your absence; if it is reasonable, you will not lose the participation points. Do not e-mail me to tell me why you were absent, you must write a note on your next critique (so I have it in front of me when I'm entering grades).
Classroom rules: You may not use laptops, tablets, smartphones, or other electronic devices during lectures (the first half of the semester), because your classmates will be distracted when you look at something more interesting than my lecture. If I see you using such devices, I'll assume you're looking at porn and mock you accordingly. The only exception is February 17, when you should bring a laptop or tablet to class so you can practice your literature searching skills.
During the presentations in the second half of the semester, you may use a laptop or tablet to follow along in the paper that one of your classmates is presenting. However, I'll be sitting in the back of the room during presentations, and if I see you looking at something other than the paper, I'll throw an eraser at the back of your head.
Office hours: I will not have formal office hours; if you'd like to talk to me, feel free to call me, e-mail me, or drop by. I'm generally at my office on Tuesdays and Thursdays. On other days I'm working at home and can be reached by e-mail.
Here is the schedule of lecture topics.
|Tuesday||Feb. 10||Introduction; measuring genetic variation|
|Thursday||Feb. 12||More on measuring genetic variation|
|Tuesday||Feb. 17||Literature research||Bring a laptop to class|
|Thursday||Feb. 19||Mutation and recombination; Random drift and the neutral model|
|Tuesday||Feb. 24||Migration||Topic choice due for term paper|
|Tuesday||March 3||More on selection|
|Thursday||March 5||Codon bias and the nearly neutral model|
|Thursday||March 12||dN/ds, PAML, and MK tests|
|Tuesday||March 17||Tajima and HKA tests|
|Thursday||March 19||Geographic variation|
|Tuesday||March 24||Review for exam|
|Thursday||March 26||Exam (see the study guide)|
|Tuesday||March 31||---||Spring Break|
|Thursday||April 2||---||Spring Break|
|Tuesday||April 7||John McDonald
How to give a good presentation
|Thursday||April 9||John McDonald
Carroll, S.P., Dingle, H., and Klassen, S.P. 1997. Genetic differentiation of fitness-associated traits among rapidly evolving populations of the soapberry bug. Evolution 51: 1182-1188.
Labbe, P., Berticat, C., Berthomieu, A., Unal, S., Bernard, C., Weill, M., and Lenormand, T. 2007. Forty years of erratic insecticide resistance evolution in the mosquito Culex pipiens. PLoS Genetics 3: 2190-2199.
|Tuesday||April 14||Liz Luketich
Gayral, P., Blondin, L., Guidolin, O., Carreel, F.O., Hippolyte, I., Perrier, X., and Iskra-Caruana, M.L. 2010. Evolution of endogenous sequences of banana streak virus: What can we learn from banana (Musa sp.) evolution? J. Virol. 84: 7346-7359.
Richman, D.D., Wrin, T., Little, S.J., and Petropoulos, C.J. 2003. Rapid evolution of the neutralizing antibody response to HIV type 1 infection. Proc. Natl. Acad. Sci. USA 100: 4144-4149.
|Thursday||April 16||Zack Rachell
Haddrath, O., and Baker, A.J. 2001. Complete mitochondrial DNA genome sequences of extinct birds: ratite phylogenetics and the vicariance biogeography hypothesis. Proc. Roy. Soc. B 268: 939-945.
Crow, T.J. 1995. A theory of the evolutionary origins of psychosis. Eur. Neuropsychopharmacol. 5(Suppl): 59-63.
|Tuesday||April 21||Kathie Wu
Ley, R.E., Hamady, M., Lozupone, C., et al. (11 co-authors). 2008. Evolution of mammals and their gut microbes. Science 320: 1647-1651.
Holden, M.T.G., Feil, E.J., Lindsay, J.A., et al. (45 co-authors). 2004. Complete genomes of two clinical Staphylococcus aureus strains: Evidence for the rapid evolution of virulence and drug resistance. Proc. Natl. Acad. Sci. USA 101: 9786-9791.
|Thursday||April 23||Kevin Archibald
Bradbury, I.R., Hubert, S., Higgins, B., et al. (14 co-authors). 2010. Parallel adaptive evolution of Atlantic cod on both sides of the Atlantic Ocean in response to temperature. Proc. Roy. Soc. B 277: 3725-3734.
Norton, H.L., Kittles, R.A., Parra, E., McKeigue, P., Mao, X.Y., Cheng, K., Canfield, V.A., Bradley, D.G., McEvoy, B., and Shriver, M.D. 2007. Genetic evidence for the convergent evolution of light skin in Europeans and east Asians. Molec. Biol. Evol. 24: 710-722.
|Tuesday||April 28||Travis Piser
Scott, G.R., Schulte, P.M., Egginton, S., Scott, A.L.M., Richards, J.G., and Milson, W.K. 2011. Molecular evolution of cytochrome C oxidase underlies high-altitude adaptation in the bar-headed goose. Molec. Biol. Evol. 28: 351-363.
Cheviron, Z.A., Bachman, G.C., and Storz, J.F. 2013. Contributions of phenotypic plasticity to differences in thermogenic performance between highland and lowland deer mice. J. Exp. Biol. 216: 1160-1166.
|Thursday||April 30||Mark Burgess
Pilot, M., Dahlheim, M.E., and Hoelzel, A.R. 2010. Social cohesion among kin, gene flow without dispersal and the evolution of population genetic structure in the killer whale (Orcinus orca). J. Evol. Biol. 23: 20-31.
Wlasiuk, G., and Nachman, M.W. 2010. Promiscuity and the rate of molecular evolution at primate immunity genes. Evolution 64: 2204-2220.
|Tuesday||May 5||Donald Johnson
Tan, Y., Yoder, A.D., Yamashita, N, and Li, W.H. 2005. Evidence from opsin genes rejects nocturnality in ancestral primates. Proc. Natl. Acad. Sci. USA 102: 14712-14716.
Heesy, C.P., and Ross, C.F. 2001. Evolution of activity patterns and chromatic vision in primates: morphometrics, genetics and cladistics. J. Hum. Evol. 40: 111-149.
|Thursday||May 7||Wojciech Losos
Bowcock, A.M., Kidd, J.R., Mountain, J.L., Hebert, J.M., Carotenuto, L., Kidd, K.K., and Cavalli-Sforza, L.L. 1991. Drift, admixture, and selection in human evolution: a study with DNA polymorphisms. Proc. Natl. Acad. Sci. USA 88: 839-843.
Tarazona-Santos, E., and Tishkoff, S.A. 2005. Divergent patterns of linkage disequilibrium and haplotype structure across global populations at the interleukin-13 (IL13) locus. Genes Immun. 6: 53-65.
|Tuesday||May 12||Esther Ahn
Rushton, J.P., Bons, T.A., and Hur, Y.M. 2008. The genetics and evolution of the general factor of personality. J. Res. Pers. 42: 1173-1185.
Gavrilets, S., Arnqvist, G., and Friberg, U. 2001. The evolution of female mate choice by sexual conflict. Proc. Roy. Soc. B 268: 531-539.
|Thursday||May 14||Lexi Pumilia
Klitz, W., Gragert, L., Maiers, M., Fernandez-Vina, M., Ben-Naeh, Y., Benedek, G., Brautbar, C., and Israel, S. 2010. Genetic differentiation of Jewish populations. Tissue Antigens 76: 442-458.
Puffenberger, E.G. 2003. Genetic heritage of the Old Order Mennonites of southeastern Pennsylvania. Am. J. Med. Genet. 121C: 18-31.
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This page was last revised April 1, 2015. Its URL is http://udel.edu/~mcdonald/evolsyllabus.html